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以聚N-异丙基丙烯酰胺接枝的聚酰胺作为稳定剂,以纯水作为溶剂,采用原位合成的方法合成了具有可调光热响应行为、智能响应释药行为的有机无机杂化金纳米粒,并以TEM、紫外-可见分光光度计测定其在不同温度下分别对金核的粒径和表面等离子吸收峰的影响,采用1H-NMR,IR对上述聚合物做了表征.通过紫外-可见光分光光度计测定了不同组样品的低临界溶胀/溶解温度(LCST)值,发现不同组样品LCST有一定差别,通过激光照射测定了样品的体外光热响应性能.选用难溶性吲哚美辛作为模型药物,考察了各组样品的载药释药行为.实验研究结果表明,聚N-异丙基丙烯酰胺接枝的聚酰胺修饰的金纳米粒较单独的聚合物N-聚异丙基丙烯酰胺更适宜作为多功能药物载体:具有更接近人体生理温度的LCST值,并且具有随温度变化而发生变化的光热响应性质及温度响应的药物释放行为.因此它在难溶性药物的控制释药、光热肿瘤消融领域具有较为广阔的应用前景.
Polyamides grafted with poly (N-isopropylacrylamide) were used as stabilizers and pure water was used as solvent to synthesize organic-inorganic hybrids with adjustable photothermal reaction behavior and smart response to drug release by in situ synthesis Gold nanoparticles were prepared and characterized by TEM and UV-Vis spectrophotometer. The effects of different diameters on the particle size and the surface plasmon absorption peaks of gold nanoparticles were investigated by 1H-NMR and IR. The LCST values of different samples were measured by UV-Vis spectrophotometer, and the LCST values of different samples were different. The photothermal response of samples was determined by laser irradiation. As a model drug, Maysin investigated the drug release behavior of each group of samples.Experimental results show that poly (N-isopropylacrylamide) grafted polyamidoamine nanoparticles are more stable than N-poly Propyl acrylamide is more suitable as a multi-functional drug carrier: LCST values that are closer to human physiological temperature and have the photothermal response properties that change with temperature and the drug release behavior of temperature response. It is in the controlled release of insoluble drugs, photothermal tumor ablation in the field has a more broad application prospects.