摘要目的应用基于肺结节和病人特征的肺癌风险计算器评价国家肺癌筛查试验(NLST)数据子集中恶性肺结节的可能性。材料与方法所有作者均被批准应用NLST数据,且对具有学术职务的作者豁免机构伦理委员会审批和研究对象的知情同意要求。NLST子集中有关肺结节和病人良、恶性特征输入来自加拿大温哥华团队的结节风险计算器,将这些特征与结节风险计算器中相应特征进行比较。测试多个阈值区分结节良恶性,最终选择一个最佳阈值确定NLST数据 Abstract Objective To evaluate the possibility of evaluating malignant pulmonary nodules in a subset of national lung cancer screening test (NLST) data using a lung cancer risk calculator based on characteristics of lung nodules and patients. Materials and Methods All authors were approved to apply the NLST data and exempt authors with academic positions from the institutional ethics committee approval and research subjects’ informed consent requirements. Relevance of nodules and patient benign and malignant features in the NLST subset Enter the nodule risk calculator from the Vancouver team in Canada and compare these characteristics with those of the nodular risk calculator. Test Multiple Thresholds to Differentiate Nodules from Benign and Malignant, Select an Optimal Threshold to Finalize NLST Data