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目的 探讨肿瘤坏死因子 (TNF -α)在急性胰腺炎 (AP)发病过程中的作用。方法 采用放射免疫学法检测TNF-α水平 ,并分析其与急性胰腺炎病变严重程度 (以病理切片确定 )的相关性。结果 胰腺炎组B(2 15± 90pg/ml)、胰腺炎加重组C(2 41± 75pg/ml)、胰腺炎拮抗组D(175± 2 6 8pg/ml)的血清TNF -α水平都比对照组A(2 4 1± 8 2pg/ml)明显增高 (P <0 0 5 )。结论 TNF -α在急性胰腺炎的发病过程中起重要的介导作用 ,并反映急性胰腺炎的病变程度 ,阻断TNF -α能减轻急性胰腺炎的病理损害作用。
Objective To investigate the role of tumor necrosis factor (TNF-α) in the pathogenesis of acute pancreatitis (AP). Methods The level of TNF-α was detected by radioimmunoassay and the correlation between the level of TNF-α and the severity of acute pancreatitis (determined by pathology) was analyzed. Results Serum levels of TNF-α in pancreatitis group B (2 15 ± 90 pg / ml), pancreatitis aggravated group C (2 41 ± 75 pg / ml) and pancreatitis antagonist group D (175 ± 2 6 8 pg / ml) The control group A (2 41 ± 8 2 pg / ml) was significantly higher (P <0 05). Conclusion TNF-α plays an important role in the pathogenesis of acute pancreatitis and reflects the degree of acute pancreatitis. Blocking TNF-α can reduce the pathological damage of acute pancreatitis.