胰高血糖素样肽1(GLP1)受体属于难以被小分子药物靶向作用的G蛋白偶联受体(GPCR)。Bjerre-Knudsen等发现了一个能刺激胰高血糖素依赖性胰岛素释放的小分子GLP1受体激动剂,这可能对研究治疗糖尿病的口服GLP1激动剂有帮助。在摄入食物后,GLP1能促进胰岛素的分泌,有减轻体重的作用 The glucagon-like peptide 1 (GLP1) receptor belongs to a G-protein coupled receptor (GPCR) that is difficult to be targeted by small molecule drugs. Bjerre-Knudsen et al. Found a small molecule GLP1 receptor agonist that stimulates glucagon-dependent insulin release, which may be helpful in the study of oral GLP1 agonists for the treatment of diabetes. After ingesting food, GLP1 can promote the secretion of insulin, which can reduce body weight