论文部分内容阅读
目的观察参芪扶正注射液对进展期胃癌患者免疫功能的影响。方法进展期胃癌患者82例,分为对照组40例及观察组42例,2组患者均采用ECF-L方案化疗,观察组在此基础上加用参芪扶正注射液。化疗2个周期后评价2组近期疗效、不良反应及生活质量改善情况,并比较2组化疗前1天及化疗2个周期后外周血CD_3~+、CD_4~+、CD_8~+T细胞亚群比例及NK细胞比例。结果所有患者均完成2个周期的治疗,观察组客观缓解率(ORR)为40.5%,对照组ORR为37.5%。2组ORR差异无统计学意义(P>0.05)。观察组生活质量改善率64.3%显著高于对照组的37.5%(P<0.05)。观察组化疗2个周期后CD_3~+、CD_4~+T细胞亚群、NK细胞水平、CD_4~+/CD_8~+比例均高于化疗前1天,且高于对照组,差异均有统计学意义(P<0.01)。观察组骨髓抑制、消化道反应、神经毒性发生率显著低于对照组(P<0.05)。结论参芪扶正注射液能够改善进展期胃癌化疗患者生活质量及免疫功能,减轻化疗不良反应。
Objective To observe the effect of Shenqi Fuzheng Injection on immune function of patients with advanced gastric cancer. Methods Eighty-two patients with advanced gastric cancer were divided into control group (40 cases) and observation group (42 cases). Both groups were treated with ECF-L chemotherapy. The observation group was treated with Shenqi Fuzheng Injection. After 2 cycles of chemotherapy, the short-term efficacy, adverse reactions and quality of life improvement in the 2 groups were evaluated. The CD3+, CD4+, CD8+ T cell subsets in the peripheral blood of the 2 groups before and 2 weeks after chemotherapy were compared. Ratio and ratio of NK cells. Results All patients completed 2 cycles of treatment. The ORR of the observation group was 40.5%, and the ORR of the control group was 37.5%. There was no significant difference in ORR between the two groups (P>0.05). The improvement rate of 66.3% in the observation group was significantly higher than that in the control group (37.5%) (P<0.05). After 2 cycles of chemotherapy, the proportions of CD3+, CD4+ T cell subsets, NK cells, and CD4+/CD8+ in the observation group were higher than those before chemotherapy, and were higher than those in the control group. The differences were statistically significant. Significance (P<0.01). The incidence of myelosuppression, digestive tract reaction and neurotoxicity in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Shenqi Fuzheng Injection can improve the quality of life and immune function of patients with advanced gastric cancer chemotherapy, and reduce the adverse reactions of chemotherapy.