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目的 :设计并合成了一系列六氢苯并 [a]喹嗪 4 酮类化合物 ,对其钙拮抗活性作初步研究 ;方法 :用4 5Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道 (PDC)Ca2 + 内流的影响 ;结果 :四个化合物对PDC均有显著阻滞作用 ;结论 :初步药理实验显示 ,四个化合物具有一定的钙拮抗活性
OBJECTIVE: To design and synthesize a series of hexahydrobenzo [a] quinolizin 4 ketones for preliminary study of their calcium antagonistic activity. Methods: The transmembrane flow assay was used to study the effect of target The effects of four compounds on the PDC were significantly inhibited.Conclusion: Preliminary pharmacological experiments showed that the four compounds have certain calcium antagonistic activity