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本研究旨在结合图论讨论颞叶肿瘤对整个大脑结构网络的影响以及患者认知功能变化情况.本文基于弥散张量成像技术,构建颞叶肿瘤患者以及正常对照组脑结构网络,依据纤维束连接长度,将整个脑网络分为3个子网络,对比分析各个子网络的网络参数全局效率和局部效率,进而对颞叶肿瘤患者大脑内纤维束的再生以及消亡情况做简单分析.并对两组受试者进行认知能力评估,分析患者认知能力与节点效率之间的相关性,从而得到患者大脑认知分布情况.研究结果显示,全局效率和局部效率在全脑网络结构中均无显著差异,子网络拓扑参数显示,仅在短距离子网络中,患者组较正常组有显著升高,局部参数研究结果显示,正常组均优于患者组,且患者认知能力普遍低于正常组.脑区内部纤维束再生以及不同功能区之间纤维束连接发生变化从而使得颞叶肿瘤患者脑结构网络发生重组,且患者在注意力、记忆功能、学习能力等方面较正常人有显著降低,患者额颞-顶叶部分脑区参与认知过程,特殊脑区信息处理效率的变化可间接反映认知变化情况.
This study aims to discuss the influence of temporal lobe tumor on the entire cerebral structure network and the changes of cognitive function in patients with temporal lobe tumor.Based on diffusion tensor imaging, we construct brain network of patients with temporal lobe tumor and normal control group, Length of connection, the whole brain network is divided into three sub-networks, the global efficiency and local efficiency of network parameters of each sub-network are compared and analyzed, and then the regeneration and disappearance of fiber bundles in the patients with temporal lobe tumor are analyzed briefly. Subjects underwent assessment of cognitive ability and analyzed the correlation between patient cognitive ability and node efficiency to obtain cognitive distribution in patients with brain.The results showed that global efficiency and local efficiency in the whole brain network structure were not significant Differences and sub-network topology parameters showed that in the short-distance sub-network only, the patient group was significantly higher than the normal group. The local parameter study showed that the normal group was better than the patient group, and the cognitive ability of the patients was generally lower than that of the normal group Brain tissue regeneration within the fiber bundle and fiber bundle changes between different functional areas so that patients with temporal lobe brain network structure And the patient’s cognition was significantly decreased in attention, memory and learning ability compared with normal subjects. The frontotemporal-parietal parts of brain involved in cognitive process, and the changes of special brain area information processing efficiency could indirectly reflect the cognition Changes.