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目的 观察安宫黄体酮、丹那唑及抑那通治疗女性真性性早熟的疗效。方法 采用安宫黄体酮 8～ 2 0mg/d、丹那唑 0 .2～ 0 .4mg/d及抑那通 3 0～ 5 0 μg/ (kg·月 )治疗女性真性性早熟 10 6例 ,观察治疗前后患儿第二性征、骨龄及血清性激素的变化。结果 三种药物均可抑制第二性征发育。安宫黄体酮组中 46例第二性征减退 ,10例无明显改善 ,12例有月经者 9例月经停止 ,E2 下降 ;丹那唑组所有患儿第二性征减退 ,8例有月经者 6例月经停止 ,骨龄无改变 ,血E2下降 ,FSH及LH无变化 ,治疗后血T升高 ,但在正常范围内 ;抑那通组所有患儿在治疗后第二性征减退 ,4例有月经的患儿月经停止 ,骨龄增长速度减慢 ,血E2 ,FSH及LH均下降。结论 抑那通治疗真性性早熟的疗效优于安宫黄体酮及丹那唑 ,是治疗真性性早熟的首选药物之一。
Objective To observe the curative effect of Andrinalis progesterone, Danazol and Coptidis on female sexual precocity. Methods 10 6 cases of true precocious puberty were treated with An Cheng progesterone 8 ~ 20mg / d, Danazol 3.0 ~ 0.4mg / d and 30mg / (kg · month) Changes of second sexual characteristics, bone age and serum sex hormones in children before and after treatment. Results All three drugs can inhibit the development of second sexual characteristics. In the second group, 46 cases of secondary progesterone group showed a decrease in secondary sexual characteristics, 10 cases showed no significant improvement, 9 cases of menstruation stopped menstruation and E2 decreased in 12 cases, 6 cases of menstruation stopped, bone age did not change, blood E2 decreased, FSH and LH did not change after treatment of blood T increased, but within the normal range; all the patients in the inhibition of the second group after treatment, 4 cases Children with menstruation stopped menstruation, bone growth slowed down, blood E2, FSH and LH decreased. Conclusions The efficacy of memantine in treatment of true precocious puberty is superior to that of Andongrarin and Danazol, which is one of the first choice drugs for the treatment of true precocious puberty.