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目的 介绍端粒、端粒酶的性质及其与肿瘤的关系 ,了解端粒、端粒酶在胃癌中的表达及意义。方法 综述国内外进展。结果 端粒酶活性在 85 %～ 90 %的胃癌中可以检测到 ,在表达端粒酶阳性的患者比表达阴性的患者预后要差 ,表明端粒酶阳性的胃癌恶性程度更高。结论 胃癌端粒酶活性检测不仅可用于诊断 ,且可用于表示预后 ,未来用于抑制端粒酶的药物可以提供一种副作用较少的治疗癌症的方法。
Objective To introduce the telomere and telomerase properties and their relationship with tumor and understand the expression and significance of telomere and telomerase in gastric cancer. Methods Summarizes the progress at home and abroad. RESULTS: Telomerase activity was detectable in 85% to 90% of gastric cancers, with a poorer prognosis in telomerase positive patients than in negative ones, suggesting that telomerase positive gastric cancer is more malignant. Conclusion The detection of telomerase activity in gastric cancer can be used not only for diagnosis but also for predicting prognosis. In the future, drugs for inhibiting telomerase may provide a less side-effect treatment for cancer.