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新近证明,在慢性感染的病人和黑猩猩干扰素对 HBV 成分的合成和/或维持方面有明显的抑制作用,这为更有效的治疗方法带来了新的希望。由人白细胞或人二倍体纤维母细胞制备的外源性干扰素以及由一种合成的核酸所诱导产生的内源性干扰素都是有效的。在干扰素治疗过程中,与病毒有关的 DNA 聚合酶活性、血清 HBsAg 和 HBeAg 的浓度以及肝内 HBsAg和 HBeAg 的量都降低。这些变化在大多数情况下是可逆的。但至少也有一例在治疗停止很久以后情况仍然良好。
Recently, it has been shown that chronically infected patients and chimpanzee interferons have a significant inhibitory effect on the synthesis and / or maintenance of HBV components, which brings new hope for a more effective treatment. Exogenous interferons prepared from human leukocytes or human diploid fibroblasts and endogenous interferons induced from a synthetic nucleic acid are all effective. During interferon therapy, viral-related DNA polymerase activity, serum HBsAg and HBeAg concentrations, and liver HBsAg and HBeAg levels were reduced. These changes are reversible in most cases. But at least one more case remained good long after treatment was stopped.