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采用半互穿网络技术和原位自由基聚合将生物相容性和吸水性优良的丝胶蛋白(SS)引入聚异丙基丙烯酰胺-硅酸镁锂(Poly(NIPAm-LMSH))纳米复合凝胶网络,制得高溶胀度和快速响应的SS/Poly(NIPAm-LMSH)纳米复合凝胶,研究了丝胶含量对纳米复合凝胶的孔洞形态、溶胀动力学、结晶结构、相容性和稳定性的影响。结果表明:冷冻干燥后的SS/Poly(NIPAm-LMSH)水凝胶呈多孔结构,孔洞尺寸为20~30μm,孔壁薄,为1~4μm,且随丝胶含量增加而由多面体结构变为狭长形的层状结构。相比于溶胀平衡的纯纳米复合凝胶,丝胶的引入显著提高了其溶胀度,溶胀初期属于Non-Fickian扩散,37℃10min内即可失去90%的水。丝胶在凝胶中具有良好的相容性,SS/Poly(NIPAm-LMSH)纳米复合凝胶的Tg为141~144℃,最大热分解温度为365~373℃,质量残留率随丝胶含量的增加而增大。
The sericin (SS) with excellent biocompatibility and water absorption was introduced into polyisopropylacrylamide-lithium magnesium silicate (Poly (NIPAm-LMSH)) nanocomposite by semi-interpenetrating network technology and in situ free radical polymerization (NIPAm-LMSH) nanocomposite gel with high swelling degree and fast response, the effects of sericin content on pore morphology, swelling kinetics, crystal structure, compatibility of nanocomposite gel And the stability of the impact. The results showed that the freeze-dried SS / Poly (NIPAm-LMSH) hydrogel has a porous structure with a pore size of 20-30 μm and a thin wall with a thickness of 1-4 μm. When the content of sericin increases, the structure of the polyhedron becomes Slim long layered structure. Compared with the pure nanocomposite gel with swelling equilibrium, the introduction of sericin significantly increased the swelling degree, which belongs to Non-Fickian diffusion in the early swelling phase. It can lose 90% water within 10 min at 37 ℃. The sericin has good compatibility in gel. The Tg of SS / Poly (NIPAm-LMSH) nanocomposite gel is 141-144 ℃ and the maximum pyrolysis temperature is 365-373 ℃. The mass residual rate varies with the content of sericin Increase and increase.