肿瘤坏死因子(TNF)包括TNFα和TNFβ,是一系列细胞因子的成员之一。具有明显的多效性,参于机体对炎症、创伤、恶性肿瘤和器官移植排斥反应过程中的生物学效应,并可作为同种移植排斥反应及移植物长期存活的预测指标。抗TNF治疗可延长同种移植物的存活时间,与CsA联合应用可增强抗排斥反应的效果。 Tumor necrosis factor (TNF), including TNFα and TNFβ, is a member of a series of cytokines. It has obvious pleiotropy, which is involved in the biological effects of the body on the rejection of inflammation, trauma, malignant tumor and organ transplantation and can be used as a predictor of allograft rejection and graft long-term survival. Anti-TNF treatment can extend the survival time of allografts, combined with CsA can enhance the anti-rejection effect.