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目的:通过观察慢性肾脏病患者晨尿尿蛋白/尿肌酐(Up/Ucr)和晨尿尿蛋白/尿渗透压(Up/Uosm)与24h尿蛋白定量(Pr24h)的相关性,探讨二者代替24h尿蛋白定量的可行性。方法:106例慢性肾脏病患者留取晨尿及24h尿,测定晨尿尿蛋白/尿肌酐和晨尿尿蛋白/尿渗透压比值及24h尿蛋白定量,根据肾小球滤过率(GFR)分5组,确定各组中两者与24h尿蛋白定量的相关性,根据ROC曲线确定二者分别对于24h尿蛋白定量≥1.0g、≥2.0g、≥3.0g的临界值。结果:Up/Ucr在GFR≥15ml/min时与Pr24h相关,GFR<15ml/min时无关。Up/Uosm在所有分组中均与Pr24h相关。二者分别对于Pr24h≥1.0g、≥2.0g、≥3.0g的临界值为0.98、1.96、2.98及0.96、1.99、2.95。结论:Up/Ucr和Up/Uosm均可替代24h尿蛋白定量预测蛋白尿。
OBJECTIVE: To investigate the correlation between morning urine urinary protein / urine creatinine (U / Ucr) and urolithin / urine osmotic pressure (U / Um) and 24 h urinary protein (Pr24h) in patients with chronic kidney disease Feasibility of 24 h urine protein quantitation. Methods: The morning urine and 24h urine were collected from 106 patients with chronic kidney disease. The urinary protein / creatinine and morning urine urinary protein / urinary osmotic pressure were measured and the urinary protein excretion was determined according to glomerular filtration rate (GFR) According to the ROC curve, we determined the critical value of quantitative urinary proteinuria ≥1.0g, ≥2.0g, ≥3.0g for 24 hours respectively. RESULTS: Up / Ucr correlated with Pr24h at GFR> 15ml / min and no correlation at GFR <15ml / min. Up / Uosm is related to Pr24h in all groups. The critical values for Pr24h ≧ 1.0g, ≧ 2.0g, and ≧ 3.0g, respectively, were 0.98, 1.96, 2.98 and 0.96, 1.99, 2.95. Conclusion: Both Up / Ucr and Up / Uosm can be used to quantitatively predict proteinuria instead of 24h urinary protein.