钙拮抗剂硝苯地平用于治疗冠心病和高血压,对于急性情况处方,需要很快释放药物,而对于持续治疗,特别对于高血压病人,需要延缓药物释放。按卫生部门要求需要在静态下进行生物利用度研究。按双盲交叉设计,对22名(女16名,男6名)受试者,年龄23～49岁,体重55～84kg,身高1.63～1.82m,在静态下服用试验制剂20mg硝苯地平缓释糖衣片(商品名Corinfar)或对照制剂20mg硝苯地平糖衣片。交叉服用两种制剂相隔6周。在服药前、后 Nifedipine, a calcium antagonist, is used to treat coronary heart disease and high blood pressure, requiring rapid release of the drug for acute prescriptions, and for sustained treatment, especially for hypertensive patients, to delay drug release. As required by the health department, bioavailability studies need to be performed statically. According to the double-blind crossover design, 22 (16 female and 6 male) subjects, aged 23-49 years old, weighing 55-84kg and height 1.63-1.82m, were given the test formulation of 20mg nifedipine Sugar-coated tablets (trade name Corinfar) or control preparations 20 mg nifedipine sugar-coated tablets. Interleaving two formulations separated by 6 weeks. Before taking medicine, after