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18只日本大耳白雄兔随机分为输精管结扎组(VG)和假手术组(SOG)。术后第16月进行睾丸功能与形态学观察。结果表明:血清睾酮含量两组无明显差异(p>0.05);睾丸环-磷酸腺苷cAMP含量与血管紧张素Ⅰ转换酶(ACE)活力,Na~+,K~+-ATP酶及Mg~(++)-ATP酶比活性呈显著的正相关,两组比较,VG的cAMP含量与酶活力均明显地低于SOG;输精管结扎术后自身免疫性睾丸炎可能是睾丸生精功能抑制的重要原因。
Eighteen Japanese white rabbits were randomly divided into vasectomy group (VG) and sham operation group (SOG). Testicular function and morphology were observed 16 months after operation. The results showed that serum testosterone level had no significant difference between the two groups (p> 0.05). The content of cAMP in testis and the activity of angiotensin I converting enzyme (ACE), Na +, K + (++) -ATPase activity was significantly positive correlation between the two groups, the VG cAMP content and enzyme activity were significantly lower than the SOG; vas deferens after ligation of autoimmune orchitis may be testicular spermatogenic inhibition important reason.