目的探讨ＳｉＯ２刺激肺泡巨噬细胞（ＰＡＭ）的上清液对肺泡上皮细胞的迁移和增殖的影响。方法采用Ｂｏｙｄｅｎｃｈａｍｂｅｒ系统，观察空白对照（０μｇ／ｍｌＳｉＯ２）和２００μｇ／ｍｌＳｉＯ２刺激ＰＡＭ的上清液（１．０×１０６～１．５×１０６ＰＡＭ／ｍｌ）对貂肺泡上皮细胞株Ｍｖ１ｌｕ细胞的迁移和增殖的影响。结果２００μｇ／ｍｌＳｉＯ２ＰＡＭ的上清液对Ｍｖ１ｌｕ细胞的迁移和增殖效应明显低于空白对照组。结论ＳｉＯ２刺激ＰＡＭ的上清液对Ｍｖ１ｌｕ细胞的迁移和增殖均有明显的抑制作用；ＳｉＯ２吸入可以刺激ＰＡＭ分泌某些因子，对肺泡上皮细胞损伤的修复产生抑制作用。 Objective To investigate the effect of SiO2-stimulated supernatant of alveolar macrophages (PAM) on the migration and proliferation of alveolar epithelial cells. Methods The BoydenCember system was used to observe the effects of blank control (0μg / mlSiO2) and 200μg / ml supernatant of SiO2-stimulated PAM on the Mv1 cell line of mink alveolar epithelial cells (1.0 × 106 ~ 1.5 × 106PAM / ml) lu cell migration and proliferation. Results The migration and proliferation effects of 200μg / ml supernatant of Si02PAM on Mv1lu cells were significantly lower than those of the blank control group. Conclusion Silica stimulated supernatant of PAM could significantly inhibit the migration and proliferation of Mv1lu cells. Silica inhalation could stimulate the secretion of some factors and inhibit the repair of alveolar epithelial cell injury.