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目的观察硝苯地平缓释片联合依那普利对老年高血压患者的疗效。方法 >60岁的高血压患者70例,随机分为治疗组(36例)和对照组(34例),治疗组口服国产硝苯地平缓释片10 mg/d和依那普利10～20 mg/d,对照组口服吲哒帕胺2.5 mg/d,治疗4周,观察治疗前后的血压变化、临床表现和不良反应。结果治疗组降压效果显著高于对照组,两组差异有统计学意义(P<0.05),且严重不良反应少。结论硝苯地平缓释片联合依那普利较吲哒帕胺更能明显降低老年高血压患者的血压,且不良反应少。
Objective To observe the efficacy of nifedipine sustained-release tablets combined with enalapril in elderly patients with hypertension. Methods 70 hypertensive patients aged 60 years were randomly divided into treatment group (36 cases) and control group (34 cases). The treatment group was treated with oral nifedipine 10 mg / d and enalapril 10-20 mg / d. The control group received indapamide 2.5 mg / d for 4 weeks. The changes of blood pressure, clinical manifestations and adverse reactions before and after treatment were observed. Results The antihypertensive efficacy of the treatment group was significantly higher than that of the control group, the difference between the two groups was statistically significant (P <0.05), and serious adverse reactions less. Conclusion Nifedipine sustained-release tablets combined with enalapril can significantly lower the blood pressure of elderly hypertensive patients than indapamide, with less adverse reactions.