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真正有效的疫苗应能激发体液和细胞免疫应答,即能刺激两个主要CD4细胞亚群:TH1细胞和TH2细胞,前者产生白细胞介素2(IL-2)和γ干扰素(IFN-γ),与细胞免疫力有关;后者产生IL-4、IL-5和IL-10,与体液免疫力有关。 美国宾夕法尼亚大学兽医学院和Wistar研究所的研究者曾用硕大利什曼原虫和BALB/c小鼠进行研究,该动物对硕大利什曼原虫感染只产生TH2应答,因此,最终死亡。而C3H/HeN品系小鼠可产生两倍强度的TH1和TH2应答,体内产生的IFN-γ似能保护这类小鼠。但是,BALA/c小鼠摄入IFN-γ并用硕大利什曼原虫攻击
A truly effective vaccine should stimulate both humoral and cellular immune responses by stimulating two major subsets of CD4 cells, TH1 and TH2, which produce interleukin 2 (IL-2) and interferon gamma (IFN-γ) , And cellular immunity; the latter produces IL-4, IL-5 and IL-10, and humoral immunity. Researchers at the University of Pennsylvania School of Veterinary Medicine and the Wistar Institute have conducted studies with Leishmania major and BALB / c mice that eventually developed a TH2 response to L. major infection and therefore eventually died. While C3H / HeN strain mice produced twice as intense TH1 and TH2 responses, IFN-γ produced in vivo seemed to protect these mice. However, BALA / c mice ingest IFN-γ and challenge with L. major