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本文对历经20年三代胆道结石灌注溶石药剂研究进行小结。采用一至三代药物复方胆汁酸钠、复方桔油乳剂及复方甲基叔丁醚对576例胆道结石进行灌注溶石治疗。结石消失率分别为43.41%、49.17%及41.72%。有效率分别为63.56%、86.95%和85.05%;副作用发生率分别为22.48%、11.39%和14.94%。溶石途径经过了初期的“T管”、T管(?)道改置“F管”发展至后期经皮肝穿留置气囊导管和十二指肠镜留置气囊鼻胆管等方法,全组随访438例(随访率76.04%)。结果表明:三代溶石药物均具有溶解胆固醇和色素结石的特点;置管方式和药物、结石特征等有关;ERBD气囊导管被认为是目前无损伤性理想的灌注溶石途径。
In this paper, after 20 years of three generations of biliary stones perfused limestone research summary. One to three generations of compound bile sodium, compound orange oil emulsion and compound methyl tert-butyl ether were used to treat 576 cases of biliary calculi with percutaneous lysis treatment. The rate of stone disappearance was 43.41%, 49.17% and 41.72% respectively. The effective rates were 63.56%, 86.95% and 85.05% respectively. The incidence rates of side effects were 22.48%, 11.39% and 14.94% respectively. Limestone pathway through the initial “T tube”, T tube (?) Road, “F tube” development to the late percutaneous transhepatic balloon catheter placement and duodenal endoscopic balloon nasobiliary duct and other methods, the whole group of follow-up 438 cases (follow-up rate was 76.04%). The results showed that all the three generations of Limestone drugs had the characteristics of dissolving cholesterol and pigmented stones. The way of catheterization was related to the characteristics of drugs and stones. ERBD balloon catheter was considered as the ideal path of percutaneous lysis without damage.