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目的 :研究康莱特注射液对原发性肝癌患者肿瘤细胞的细胞毒性和协同化疗药物增敏的作用。方法 :用 MTT法测定 31例肝癌患者肿瘤细胞对康莱特和常用 5种化疗药物及康莱特分别与单个化疗药联合作用的敏感性 ,并与对照组比较。结果 :康莱特和卡铂、顺铂、5 -氟尿嘧啶等化疗药对肿瘤细胞的平均抑制率达 30 %以上 ;康莱特联合的顺铂、丝裂毒素、5 -氟尿嘧啶、卡铂等药的平均抑制率明显高于单药组 ,P<0 .0 5。结论 :康莱特注射液对群体原发性肝癌患者肿瘤细胞有较好的抗肿瘤和化疗增敏双作用。
Objective: To study the effect of Kanglaite injection on the cytotoxicity and synergistic chemotherapeutic sensitization of tumor cells in primary liver cancer patients. METHODS: The sensitivity of tumor cells of 31 patients with HCC to Kanglaite and commonly used chemotherapeutic agents and Kanglaite combined with single chemotherapeutic agents was determined by MTT method and compared with the control group. Results: The average inhibition rate of tumor cells by Kanglaite and carboplatin, cisplatin, 5-fluorouracil, etc. reached over 30%; the average of Kanglaite combined cisplatin, mitomycin, 5-fluorouracil, carboplatin, etc. The inhibition rate was significantly higher than that of the single drug group, P<0.05. Conclusion: Kanglaite injection has good antitumor and chemosensitization effects on tumor cells in patients with primary liver cancer.