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目的:探讨18F-FDGPET/CT在妇科恶性肿瘤诊断及随访中的应用价值。方法:对33例妇科恶性肿瘤患者(17例原发肿瘤、16例术后可疑复发或转移)行18F-FDGPET/CT显像,与常规影像学结果进行分析比较。结果:17例原发肿瘤患者中,PET/CT和常规影像学对原发病灶的诊断无统计学差异;两种方法对淋巴结转移的诊断敏感性、特异性、准确性、阳性预测值和阴性预测值分别为:85.7%vs28.6%,100%vs100%,94.1%vs70.6%,100%vs100%和90.9%vs66.7%,两者比较敏感性有统计学差异;对转移淋巴结数目的诊断准确性分别为92.3%,46.2%,两者比较有统计学差异。16例可疑复发或转移患者中,PET/CT及常规影像学对病例数的诊断无统计学差异,对病灶数目的诊断敏感性、特异性、准确性、阳性预测值及阴性预测值分别为:76.9%vs48.7%,77.8%vs66.7%,77.1%vs52.1%,93.8%vs86.4%及43.8%vs23.1%,两者比较敏感性、准确性有统计学差异。结论:18F-FDGPET/CT作为一种有效的无创性影像学诊断方法,在妇科恶性肿瘤的诊断及随访过程中具有重要的临床应用价值。
Objective: To explore the application value of 18F-FDG PET/CT in diagnosis and follow-up of gynecologic malignancy. Methods: Thirty-three gynecologic malignancy patients (17 primary tumors, 16 postoperative recurrences or metastases) underwent 18F-FDG PET/CT imaging, and compared with conventional imaging findings. RESULTS: Among the 17 primary tumor patients, PET/CT and conventional imaging had no significant difference in the diagnosis of primary lesions; the diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative value of the two methods for the diagnosis of lymph node metastases were not statistically different. The predicted values were: 85.7% vs 28.6%, 100% vs 100%, 94.1% vs 70.6%, 100% vs 100%, and 90.9% vs 66.7%. The statistically significant differences were found between the two; the number of metastatic lymph nodes The diagnostic accuracy was 92.3% and 46.2%, respectively. There was a statistically significant difference between the two. Among 16 suspected recurrent or metastatic patients, PET/CT and conventional imaging had no significant difference in the number of cases. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the number of lesions were: 76.9% vs 48.7%, 77.8% vs. 66.7%, 77.1% vs. 52.1%, 93.8% vs. 86.4%, and 43.8% vs. 23.1%. There was a statistically significant difference in sensitivity and accuracy. Conclusion: 18F-FDG PET/CT is an effective non-invasive imaging diagnosis method, which has important clinical application value in the diagnosis and follow-up of gynecological malignancy.