论文部分内容阅读
目的比较胰岛素泵持续皮下输注与多次皮下注射胰岛素强化治疗1型糖尿病患儿疗效和安全性。方法选取医院2014年6月-2016年2月收治的1型糖尿病患儿84例,随机分为胰岛素多次皮下注射组(MSII组)和连续皮下注射组(CSII组)各42例,分别给予多次皮下注射胰岛素和胰岛素泵持续皮下输注治疗,比较2组患儿空腹血糖、餐后2h血糖、血糖达标时间、使用胰岛素量、低血糖发生率等情况。结果治疗前,2组患儿空腹血糖和餐后2h血糖比较无差异无统计学意义(P>0.05);治疗后,CSII组空腹血糖和餐后2h血糖变化明显优于MSII组,差异有统计学意义(P<0.05);CSII组血糖达标时间、使用胰岛素量、低血糖发生率等明显优于MSII组,差异有统计学意义(P<0.05)。结论胰岛素泵持续皮下输注与多次皮下注射胰岛素强化治疗1型糖尿病患儿相比,能快速、平稳地控制高血糖症状,减少低血糖发生率,是一种有效而安全的治疗方法。
Objective To compare the efficacy and safety of continuous subcutaneous infusion of insulin pump with multiple subcutaneous insulin in patients with type 1 diabetes. Methods Eighty-four children with type 1 diabetes admitted from June 2014 to February 2016 in our hospital were randomly divided into multiple subcutaneous injections of insulin (MSII group) and continuous subcutaneous injection group (CSII group) in 42 cases, respectively Subcutaneous hypodermic injection of insulin and insulin pump subcutaneous infusion therapy, fasting blood glucose in patients with 2 groups, 2h postprandial blood glucose, blood glucose compliance time, the use of insulin, the incidence of hypoglycemia and so on. Results Before treatment, there was no significant difference in fasting blood glucose and postprandial blood glucose between the two groups (P> 0.05). After treatment, the changes of fasting blood glucose and postprandial 2h blood glucose in CSII group were significantly better than those in MSII group (P <0.05). The time of reaching the goal of blood glucose, the amount of insulin used, the incidence of hypoglycemia in CSII group were significantly better than those in MSII group (P <0.05). Conclusion Continuous subcutaneous infusion of insulin pump compared with multiple subcutaneous insulin injections in children with type 1 diabetes can quickly and smoothly control the symptoms of hyperglycemia and reduce the incidence of hypoglycemia, which is an effective and safe treatment.