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Objective:To evaluate the in rivo antiplasmodial activities of the extract and fractions(n-hexane. chloroform,ethylacetate.butanol.aqueous) of the whole plant in Plasmodium berghei berghei infected mice.Methods:Oral administrations of the extract(200.400,and 600 my/kg) of Eleacine indica and fractions(400 mg/kg) were screened in the 4-day.repository and curative tests. Chloroquine(5 mg/kg).pyrimethamine(1.2 mg/kgi and artesunate(5 mg/kgi were used as controls. Results:The extract showed significant[P< 0.05-0.001) dose-dependent,antiplasmodial activity in the 4-day.repository and curative tests and increased the survival times of the infected mice. All the fractions exhibited significant antiplasmodial activity with the highest being ethylacetate fraction.Conclusions:Eleucine indica extract and fractions possess antimalarial activity which confirms the ethnobotanical use of this plant as a malarial remedy and opens a new highway to further investigate its potentials in the on-going fight against malaria.
Objective: To evaluate the in rivo antiplasmodial activities of the extract and fractions (n-hexane. Chloroform, ethylacetate.butanol.aqueous) of the whole plant in Plasmodium berghei berghei infected mice. Methods: Oral administrations of the extract (200.400, and 600 (400 mg / kg) were screened in the 4-day. repository and curative tests. Chloroquine (5 mg / kg) .pyrimethamine (1.2 mg / kg i and artesunate used as controls. Results: The extract showed significant [P <0.05-0.001) dose-dependent, antiplasmodial activity in the 4-day. repository and curative tests and increased the survival times of the infected mice. All the fractions demonstrated significant antiplasmodial activity with the highest being ethylacetate fraction. Conclusions: Eleucine indica extract and fractions with antimalarial activity which confirms the ethnobotanical use of this plant as a malarial remedy and opens a new highway to yet investigate its its potentials in the on-going figh t against malaria.