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目的:研究CD1α分子,趋化因子人巨噬细胞炎性蛋白-3α(CCL20/MIP-3α)在宫颈癌组织中的表达及其相关性,探讨其在宫颈癌免疫逃逸机制中的作用。方法:应用免疫组化PV-6000通用二步法检测CD1α和趋化因子CCL20/MIP-3α在正常宫颈组织及宫颈癌组织中的表达,并分析两者之间的相关性。结果:CD1α和CCL20/MIP-3α在宫颈癌中的表达均明显降低(P均<0.01);CD1α与CCL20/MIP-3α在宫颈癌中的表达显著相关(P<0.01)。结论:在宫颈癌组织中,趋化因子的减少导致抗原提呈细胞数量下降,不足以引起肿瘤局部免疫反应而导致了宫颈局部病变的侵袭及发展。
Objective: To investigate the expression and correlation of CD1α and chemokine human macrophage inflammatory protein-3α (CCL20 / MIP-3α) in cervical cancer and to explore its role in the mechanism of cervical cancer immune escape. Methods: The expression of CD1α and chemokines CCL20 / MIP-3α in normal cervical tissues and cervical cancer tissues were detected by immunohistochemical PV-6000 two-step method. The correlation between them was analyzed. Results: The expressions of CD1α and CCL20 / MIP-3α in cervical cancer were significantly decreased (all P <0.01). The expression of CD1α and CCL20 / MIP-3α in cervical cancer were significantly correlated (P <0.01). Conclusion: In cervical cancer, the decrease of chemokines leads to the decrease of the number of antigen-presenting cells, which is not enough to cause tumor local immune response and lead to the invasion and development of cervical lesions.