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目的:研究和探讨如何提高我国早期胃癌的病理诊断和临床有效治疗治方法。方法:标本选自2010年6月至2014年6月8200例电子胃镜活检,其中病理诊断为重度非典型增生的病例42例,对其进行HE染色和免疫组织化学P53,Ki67染色进行观察。结果:42例均为高级别上皮内瘤变,其中30例病变局限于粘膜层,10例不同程度侵及粘膜下层,2例侵及粘膜下层基底部,免疫组织化学P53,Ki67染色阳性率均在于25%,少数大于75%。结论:如何做到病理、临床、患者对早期胃癌的统一认知是提高早期胃癌的病理诊断与临床合理治疗的有效方法。
Objective: To study and explore how to improve the pathological diagnosis of early gastric cancer in our country and the effective clinical treatment. Methods: The samples were collected from 8200 electronic gastroscopic biopsies from June 2010 to June 2014. Of them, 42 cases were diagnosed as severe atypical hyperplasia. HE staining and immunohistochemical staining of P53 and Ki67 were performed. Results: All the 42 cases were high-grade intraepithelial neoplasia. Among them, 30 cases were localized in mucosa, 10 cases invaded submucosa and 2 cases invaded submucosa. Immunohistochemical staining of p53 and Ki67 Is 25%, a few more than 75%. Conclusion: How to achieve pathological, clinical, patients with early awareness of early gastric cancer is to improve the pathological diagnosis of early gastric cancer and effective treatment of clinically effective method.