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目的：观察庆大霉素缓释片与奥美拉唑联合治疗幽门螺旋杆菌（ＨＰ）感染的消化性溃疡与慢性胃炎的疗效。方法：１５６例病人（男性１１２例，女性４４例，年龄４５±ｓ１６ａ）均分３组：Ｉ组ｐｏ庆大霉素缓释片８０ｍｇ，ｂｉｄ×４ｗｋ；Ｉ组ｐｏ奥美拉唑２０ｍｇ，ｑｄ×４ｗｋ；联合用药（ＩＩ）组ｐｏ庆大霉素缓释片８０ｍｇ，ｂｉｄ×２ｗｋ，同时ｐｏ奥美拉唑２０ｍｇ，ｑｄ×４ｗｋ。结果：溃疡愈合率，３组依次分别为７５％，７８％和９４％，Ｐ＞０．０５。对胃炎有效率分别为７０％，７５％和８５％，Ｐ＞０．０５。对ＨＰ的根除率，分别为１５％，３８％和８１％，Ｐ＜０．０１。结论：联合用药对消化性溃疡及慢性胃炎的疗效与单独用药相比，无明显差异，但对ＨＰ的根除则联合用药明显。
Objective: To observe the curative effect of gentamicin sustained-release tablets combined with omeprazole in the treatment of peptic ulcer and chronic gastritis with Helicobacter pylori (HP) infection. Methods: 156 patients (112 males, 44 females, age 45 ± s16a) were divided into 3 groups: Group I gentamicin extended release tablets 80mg, bid × 4wk; Group I omeprazole 20mg, qd × 4wk; combination therapy (II) group ge gentamicin sustained release tablets 80mg, bid × 2wk, while po omeprazole 20mg, qd × 4wk. Results: The healing rate of ulcer was 75%, 78% and 94% respectively in 3 groups, P> 0.05. The gastritis effective rates were 70%, 75% and 85%, P> 0.05. Eradication rates for HP were 15%, 38% and 81%, respectively, P <0.01. Conclusion: The combination of drugs on peptic ulcer and chronic gastritis curative effect compared with the drug alone, no significant difference, but the combination of HP eradication was significantly.