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烟酸(NA)可抑制和逆转动物由霍乱毒素和大肠杆菌耐热肠霉素引起的肠分泌,减少人胰腺肿瘤相关性腹泻,是一种可能应用于临床的抗分泌药物。本文报告作者等在严重霍乱患者评价NA抗分泌作用的随机对照试验结果。全组病例均满足下列标准:①水泻史<48小时;
Nicotinic acid (NA) can inhibit and reverse animal intestinal secretion caused by cholera toxin and Escherichia coli heat-resistant enteromycin and reduce human pancreatic tumor-associated diarrhea. It is an anti-secrete drug that may be applied clinically. This article reports the results of randomized controlled trials in which authors evaluated the anti-secretory activity of NA in patients with severe cholera. All cases met the following criteria: ① diarrhea history <48 hours;