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解热镇痛抗炎药(NSAIDs)是一类具有解热、镇痛,多数还有抗炎、抗风湿作用的药物。据统计分析和临床研究表明,长期口服NSAIDs的患者中,有10%～25%的患者发生消化性溃疡;肾脏疾病发生的风险率是普通人群的2.1倍,且很多NSAIDs可导致新发高血压或使已有的高血压症状加重,并可导致心血管事件的发生率增加。本文就临床应用NSAIDs引起常见不良反应的危险因素和规避措施加以讨论。
Anti-inflammatory analgesic anti-inflammatory drugs (NSAIDs) is a class of antipyretic, analgesic, and most anti-inflammatory, anti-rheumatic drugs. According to statistical analysis and clinical studies, peptic ulcer disease occurs in 10% to 25% of patients with long-term oral NSAIDs; the risk of developing kidney disease is 2.1 times that of the general population and many NSAIDs can cause new-onset hypertension Or exacerbate existing symptoms of hypertension and can lead to an increased incidence of cardiovascular events. This article discusses the clinical application of NSAIDs caused by common risk factors and avoidance measures to be discussed.