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目的:了解我院急性阑尾炎手术患儿围手术期抗菌药物的应用情况。方法:对我院外科2007年1月-2008年12月急性阑尾炎手术住院患儿围手术期抗菌药物的应用品种、用药频度、联合用药、应用方法等进行回顾性分析。结果:277例小儿急性阑尾炎手术患儿共应用抗菌药物10类29种,单一用药8例(占2.89%),二联用药250例次(占90.25%),三联用药263例次(占94.95%),四联用药21例次(占7.58%)。合理应用抗菌药物91例(占32.85%),不合理应用186例(占67.15%);术前均未用抗菌药物。阑尾炎患儿抗菌药物应用率为100%,甲硝唑应用率67.0%。预防性用药108例,治疗性用药169例。结论:我院外科围手术期预防性应用抗菌药物存在疗程过长,无指征频繁换药,药物选择起点高等现象,有必要加强我院外科手术预防性使用抗菌药物的管理,进一步提高抗菌药物合理用药水平。
Objective: To understand the application of perioperative antibiotics in children with acute appendicitis in our hospital. Methods: A retrospective analysis was conducted on the types and frequency of perioperative antibacterials used in hospitalized patients with acute appendicitis from January 2007 to December 2008 in our hospital. Results: A total of 277 children with acute appendicitis were treated with 10 classes of antimicrobial agents in 29 cases, 8 cases (2.89%) with single drug, 250 cases with dual drug (90.25%), and 263 cases with triple therapy (94.95% ), Quadruple medication 21 cases (accounting for 7.58%). Ninety-one cases (accounting for 32.85%) of the rational use of antibacterials, 186 cases (67.15%) unreasonably, and no antibacterials were used before the operation. Appendicitis in children with antibacterial drug application rate of 100%, metronidazole application rate of 67.0%. Preventive medication in 108 cases, 169 cases of therapeutic medication. CONCLUSIONS: Preventive use of antimicrobial agents during perioperative period in our hospital is too long. There is no indication of frequent drug replacement and high starting point for drug selection. It is necessary to strengthen the management of preventive use of antimicrobial agents in our hospital to further improve the antimicrobial agents Rational use of medicine level.