用类固醇治疗900例重症肌无力病人,出现股骨头缺血性坏死9例,发生率为1%.我们发现骨坏死的发生与开始头3个月类固醇总量大小有关,而与总疗程无关,头3个月总量<3.6g的725例中,无1例骨坏死,而在≥3.6g的175例中骨坏死9例,高达5%,二 Treatment of 900 patients with myasthenia gravis with steroids occurred in 9 cases of avascular necrosis of the femoral head, the incidence was 1% .We found that the occurrence of osteonecrosis and the beginning of the first 3 months the total amount of steroids, but not with the total course of treatment, In the first 3 months, the total amount of <3.6g of 725 cases, no one case of osteonecrosis, and in ≥3.6g of 175 cases of osteonecrosis in 9 cases, up to 5%, two