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目的：探讨进展性脑梗死（PCI）患者血清超敏C反应蛋白（Hs-CRP）、血清淀粉样蛋白A（SAA）水平变化及临床意义。方法选取34例PCI患者为PCI组，33例非进展性脑梗死（NPCI）患者为NPCI组，34例针对血管危险因素查体者为对照组。通过胶乳增强免疫比浊法检测血清 Hs-CRP水平，酶联免疫吸附法（ELISA）检测SAA水平，并对患者采用斯堪的纳维亚卒中量表（SSS）进行评分。结果相较于NPCI组、对照组，PCI组患者在入院1、3、7、14 d血清 Hs-CRP、SAA水平明显升高（P均＜0．01），且上述蛋白水平呈正相关（P＜0．01）。此外，PCI患者第1天血清 Hs-CRP、SAA水平与入院第3、21天时SSS评分均呈明显负相关（P均＜0．05）。结论 PCI患者血清 Hs-CRP、SAA水平明显升高，其早期水平与病情程度密切相关，提示血清 Hs-CRP和SAA水平在PCI的临床进程中均起重要作用，这为PCI诊断及治疗提供了新思路。“,”Objective To investigate changes and significance of serum high-sensitivity C-reactive protein (Hs-CRP) and serum amyloid A protein (SAA)in patients with progressive cerebral infarction (PCI).Methods A total of 107 participants were divided into 3 groups:PCI group (n=34),non-progressive cerebral infarction (NPCI)group (n=33)and control group (people with vascular risk factors who received clinical examinations,n=34). Hs-CRP levels were measured with immune nephelometry,and SAA levels were evaluated with enzyme-linked immunosorbent assay (ELISA).Patients were rated with the Scandinavian Stroke Scale (SSS)score.Results Compared with the NPCI group and controls,the Hs-CRP and SAA levels in the PCI group significantly increased on day 1,3,7,and 14 (all P<0.01 ).In the PCI group,Hs-CRP and SAA levels were positively correlated (P<0.01),and Hs-CRP and SAA levels one day 1 were negative correlated with the SSS on day 3 and 21 (all P <0.05 ).Conclusion Levels of Hs-CRP and SAA are significantly enhanced in PCI patients,which are closely related with the severity of disease,sug-gesting that Serum Hs-CRP and SAA play an important role in the progression of PCI.