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目的:通过检测口腔颌面部淋巴瘤患者的EBV水平,分析其与临床病理特征之间的相关性。方法:选取2014年1月1日至2015年1月1日在新疆医科大学第一附属医院收住的口腔颌面部淋巴瘤患者,采用ISH技术检测EBV的水平,从性别、年龄、肿瘤部位、HL淋巴结内外、病灶数量、临床分期、肿瘤分型、病理类型、LDH水平等方面分析其相关性。结果:ISH技术检测EBV感染阳性者占45%。与性别、年龄、肿瘤部位、病灶数量无关(P>0.05);与HL淋巴结内外发生部位(结内60%,结外25%,P=0.012)、临床分期(I+II:30.8%,III+IV:71.4%,P=0.023)、肿瘤分型(NHL:54.9%,HL:11.1%,P=0.017)、病理类型(NKT:84.6%,BCL:23.1%,TCL:20%,HL:11.2%,P=0.034)、LDH水平(LDH>250mmol/l:60%,LDH≤250mmol/l:36%,P=0.026)有关(P<0.05);HL淋巴结内外发生部位、临床分期、肿瘤分型、病理类型、LDH水平均是颌面部淋巴瘤患者EBV感染的独立危险因素(P<0.05)。结论:EBV感染在口腔颌面部淋巴瘤患者呈高度阳性表达,HL淋巴结内外发生部位、临床分期、肿瘤分型、病理类型、LDH水平均是颌面部淋巴瘤患者EBV感染的独立危险因素。
OBJECTIVE: To detect EBV levels in patients with oral and maxillofacial lymphoma and analyze its correlation with clinicopathological features. Methods: Patients with oral and maxillofacial lymphoma who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 1, 2014 to January 1, 2015 were enrolled in this study. The level of EBV was detected by ISH technique. The gender, age, , HL lymph nodes, the number of lesions, clinical stage, tumor type, pathological type, LDH levels and other aspects of its relevance. Results: The positive rate of EBV infection detected by ISH was 45%. There was no significant correlation between HL lymph node occurrence site (60% in node, 25% in node, P = 0.012), clinical stage (I + II: 30.8%, III Tumor type (NHL: 54.9%, HL: 11.1%, P = 0.017), pathological types (NKT: 84.6%, BCL: 23.1%, TCL: 20%, HL: 11.2%, P = 0.034), LDH level (LDH> 250mmol / l: 60%, LDH≤250mmol / l: 36%, P = 0.026) Typing, pathological type and LDH level were independent risk factors of EBV infection in maxillofacial lymphoma (P <0.05). Conclusions: EBV infection is highly positive in oral and maxillofacial lymphoma. The location, clinical stage, tumor type, pathological type and LDH level of HL lymph nodes are independent risk factors of EBV infection in patients with maxillofacial lymphoma.