现将我们见到的一个家系5例Marie共济失调症(遗传性痉挛性共济失调症)报告如下。先证者(Ⅲ_1),女,46岁。因渐进性步态不稳6年就诊。患者40岁时出现双下肢力弱,走路易跌倒,步态不稳,以后逐渐出现双下肢发硬,两手动作笨拙及语言含糊。病后无吞咽困难及肢体麻木等。查体:发育正常,心肺及腹部无异常,四肢关节无畸形。神志清,言语欠流 Now we see a family of 5 cases Marie ataxia (hereditary spastic ataxia) reported as follows. The proband (Ⅲ_1), female, 46 years old. Progressive gait instability for 6 years treatment. At age 40, the patient developed weakness in both lower extremities, walking easily, and unsteady gait. Later, her lower extremities became harder and harder with both hands clumsy and vague. No dysphagia after swallowing and limb numbness. Physical examination: normal development, no abnormal heart and lung and abdomen, limb deformities without deformity. Consciousness, the words owed