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目的：研究胃原发性绒毛膜癌的组织学特点，探讨其组织学的发生。方法：对１例残胃原发性绒毛膜癌进行尸检，组织学观察，应用免疫组织化学研究其组织学的发生。结果：肿瘤表现单一的绒毛膜癌形态伴有坏死和出血，肿瘤转移至肝脏、双肺及胃周围淋巴结。免疫组化肿瘤细胞表达ＨＣＧ阳性，部分肿瘤细胞表达ＣＫ阳性。在目前英文文献报道的４８例胃原发性绒毛膜癌中，２８．３％病例以单一的绒毛膜癌形态，１３％的病例胃为腺癌而转移灶为绒毛膜癌，５８．７％的病例为腺癌、低分化癌和绒毛膜癌。结论：胃原发性绒毛膜癌发生可能为：（１）腹部的异位性索，（２）性索绒毛膜癌的转移，（３）胃的畸胎瘤，（４）胃粘膜的多能干细胞分化癌变，（５）胃的腺癌或未分化癌细胞去分化。
Objective: To study the histological features of primary choriocarcinoma of the stomach and explore its histological occurrence. METHODS: One case of residual chorionic carcinoma of the stomach was subjected to autopsy, histological observation, and histology was studied by immunohistochemistry. RESULTS: The appearance of choriocarcinoma with a single tumor was associated with necrosis and hemorrhage. The tumors were metastasized to the liver, lungs, and lymph nodes around the stomach. Immunohistochemically, tumor cells express HCG positive and some tumor cells express CK positive. Of the 48 cases of primary choriocarcinoma of the stomach reported in the current English literature, 28.3% were in a single choriocarcinoma, 13% were gastric adenocarcinoma, and the metastatic foci were choriocarcinoma, 58.7%. The cases were adenocarcinoma, poorly differentiated carcinoma and choriocarcinoma. Conclusions: Gastric primary choriocarcinoma may be: (1) abdominal heterotopic cord, (2) metastatic chorionic carcinoma, (3) gastric teratoma, (4) gastric mucosa Stem cells differentiate into carcinomas, (5) Gastric adenocarcinoma or undifferentiated cancer cells dedifferentiate.