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目的探讨烟酸与氟伐他汀钠联合治疗对老年动脉粥样硬化患者超敏C-反应蛋白与血同型半胱氨酸的影响。方法将住院CHD老年患者80例分为治疗组40例与对照组40例,对照组使用氟伐他汀钠治疗,治疗组在对照组用药的基础上加服烟酸治疗。结果经过治疗后,治疗组IMT有明显缩小(P<0.05),对照组无明显变化。两组hsCRP与HCY值都有明显下降(P<0.05或P<0.01),但是治疗组的下降幅度明显高于对照组(P<0.05)。结论烟酸与氟伐他汀钠联合治疗老年动脉粥样硬化能明显降低超敏C-反应蛋白与血同型半胱氨酸水平,使颈动脉内膜中层厚度明显下降,疗效比单独使用氟伐他汀钠显著,值得推广应用。
Objective To investigate the effect of niacin combined with fluvastatin sodium on hypersensitive C-reactive protein and homocysteine in senile patients with atherosclerosis. Methods Eighty elderly patients with CHD were divided into treatment group (40 cases) and control group (40 cases). The control group was treated with fluvastatin sodium. The treatment group was given nicotinic acid treatment on the basis of the control group. Results After treatment, the treatment group IMT significantly reduced (P <0.05), the control group no significant change. The hsCRP and HCY values in both groups were significantly decreased (P <0.05 or P <0.01), but the decrease in the treatment group was significantly higher than that in the control group (P <0.05). Conclusions The combination of niacin and fluvastatin sodium in the treatment of senile atherosclerosis can significantly reduce the level of hypersensitive C-reactive protein and blood homocysteine and cause a significant decrease of carotid artery intima-media thickness. Compared with fluvastatin alone Sodium is significant and worth promoting.