目的　探讨痰液中一氧化氮（ Ｎ Ｏ） 代谢终产物———亚硝酸盐／ 硝酸盐（ Ｎ Ｏ２／ Ｎ Ｏ３） 测定在哮喘临床中的应用价值。方法　应用 Ｇｒｉｅｓｓ 重氮法测定４５ 例不同时期、不同程度哮喘患者及１５ 例慢性支气管炎（ 慢支） 合并肺心病急性发作期患者痰液、血清 Ｎ Ｏ２／ Ｎ Ｏ３ 含量，同步测定哮喘患者痰液中嗜酸细胞阳离子蛋白（ Ｅ Ｃ Ｐ） 水平及肺通气功能。结果　哮喘轻、中、重度发作期患者痰液 Ｎ Ｏ２／ Ｎ Ｏ３ 中位数浓度（ 分别为１３１ μｍｏｌ／ Ｌ、１３６ μｍｏｌ／ Ｌ） 与缓解期组（８５ μｍｏｌ／ Ｌ） 及正常对照组（６３ μｍｏｌ／ Ｌ） 比较，差异有显著性（ Ｐ＜ ００５） ；发作期组与缓解期组比较差异有显著性（ Ｐ＜ ０ ．０５） ；慢支合并肺心病急性发作期患者痰液 Ｎ Ｏ２／ Ｎ Ｏ３ 水平（３３ μｍｏｌ／ Ｌ） 与各哮喘组及正常对照组比较，差异有显著性（ Ｐ＜ ００５） 。缓解期及发作期哮喘患者痰液 Ｎ Ｏ２／ Ｎ Ｏ３ 与一秒钟用力呼气容积占预计值百分比（ Ｆ Ｅ Ｖ１ 占预计值％ ）间呈显著负相关（ｒ 分别＝ － ０５８７ 、－ ０４８５ ， Ｐ 均＜ ００５） ；而痰液 Ｎ Ｏ２／ Ｎ Ｏ３ 与 Ｅ Ｃ Ｐ 间呈 Objective To investigate the value of nitrite / nitrate (N O2 / N O3), the end product of nitric oxide (N O) metabolism in sputum, in the clinical application of asthma. Methods 45 patients with different stages of asthma and 15 chronic bronchitis (chronic bronchitis) with sputum and serum N 2N / O 3 levels in patients with acute episode of pulmonary heart disease were detected by Griess diazotization method. Eosinophil cationic protein (E C P) levels in sputum of patients with asthma and pulmonary ventilation. Results The median sputum N 2N / O 3 concentrations (131 μmol / L, 136 μmol / L) and 85 μmol / L (n = The difference was significant (P <005) between the control group (63 μmol / L) and the control group (P <0.05). The acute phase of chronic bronchitis complicated with pulmonary heart disease There was a significant difference (P <005) between sputum N 2N / O 3 level (33 μmol / L) and asthma group and normal control group. There was a significant negative correlation between N O2 / N O3 of sputum and forced expiratory volume of one second in the remission and attack phases (F E V1, predicted value%) (r = -0  587, - 0  485, P <005); while sputum N O  2 / N O  3 and E C P was