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不同浓度的“消癃通闭”浸出液与犬大脑皮层粗制膜及IBE~(125)作用,测定“消癃通闭”对IBE~(125)与犬大脑皮层α_1-AR结合的抑制作用。结果显示“消癃通闭”对IBE~(125)犬大脑皮层的结合呈竞争性拮抗作用,IC_(50)为34.0±6.0g/L,Hill系数为0.70±0.06。佐证本方剂具有α_1-AR拮抗作用。
The inhibitory effects of “elimination of convulsions and open-closes” on the binding of IBE125 to canine cerebral cortex α_1-AR were determined by different concentrations of “elimination of convulsions and open” leachate and canine cerebral cortex crude membrane and IBE~(125). The results showed that the “removal of convulsions and obstructions” showed competitive antagonism on the binding of IBE-125 canine cerebral cortex with IC_ (50) of 34.0 ± 6.0 g/L and Hill coefficient of 0.70 ± 0.06. It is evidence that the prescription has α_1-AR antagonism.