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目的:探讨炮制前后的六君子汤有效成分变化,及其与缓解化疗消化道反应的关系。方法:以高效液相色谱法对六君子汤中党参炔苷、白术内酯Ⅱ、橙皮苷和半夏总生物碱4种主要活性成分进行含量测定,对比生用及炮制后有效成分的变化。同时给45例化疗患者口服特定炮制后的六君子汤煎剂,并以生用的六君子汤煎剂为对照组。观察治疗前后两组患者消化道反应症状的变化情况。结果:炮制后六君子汤中党参炔苷、白术内酯Ⅱ、橙皮苷和半夏总生物碱4种有效成分含量较生用均有明显增加。临床治疗后治疗组患者消化道反应症状较对照组显著减少、减轻(P<0.01)。结论:特定炮制后的六君子汤有效成分含量明显升高,可能增强了对化疗消化道反应的治疗作用。
Objective: To investigate the changes of the active ingredients of Liujunzi Decoction before and after processing and its relationship with the relief of the digestive tract reaction of chemotherapy. Methods: The contents of Ciprofloxacin, Atractyloside Ⅱ, Hesperidin, and Pinellia ternate in Liujunzi Decoction were determined by HPLC. Compared with the change of active ingredients . At the same time to 45 patients with chemotherapy after oral administration of specific Liu Junzi decoction, and raw Liu decoction decoction for the control group. Observed before and after treatment of two groups of patients with gastrointestinal symptoms changes. Results: The contents of Ciprofloxacin, Atractyloside Ⅱ, Hesperidin and total alkaloids in Liujunzi Decoction were significantly higher than those in raw materials. After treatment, the symptoms of digestive tract reaction in the treatment group were significantly reduced and alleviated compared with the control group (P <0.01). Conclusion: The content of active ingredients in Liujunzi Decoction after the specific preparation is obviously increased, which may enhance the therapeutic effect on the digestive tract reaction of chemotherapy.