论文部分内容阅读
目的探讨IgA肾病患者尿中结缔组织生长因子(CTGF)水平与小管间质病变的关系。方法选择IgA肾病患者52例,按肾活检小管间质病变程度分为四组,正常对照组15例,应用ELISA方法测定其尿中CTGF分泌水平,并检测尿蛋白定量、血肌酐、肌酐清除率及尿β2-MG等临床指标,并进行相关性分析。结果 IgA肾病患者尿中CTGF水平升高,与尿β2-MG呈正相关,而与肌酐清除率呈负相关。结论 IgA肾病患者尿中CTGF水平升高,检测尿中CTGF的水平可能成为评价慢性肾小球肾炎患者肾脏病变严重程度的指标。
Objective To investigate the relationship between urine levels of connective tissue growth factor (CTGF) and tubulointerstitial lesions in patients with IgA nephropathy. Methods Fifty-two patients with IgA nephropathy were divided into four groups according to the degree of tubulointerstitial lesion in renal biopsy and 15 normal controls. The levels of urinary CTGF secretion were measured by ELISA, and the urinary protein, serum creatinine, creatinine clearance And urinary β2-MG and other clinical indicators, and correlation analysis. Results Urinary CTGF levels in patients with IgA nephropathy were positively correlated with urinary β2-MG and negatively correlated with creatinine clearance. Conclusions The level of CTGF in the urine of patients with IgA nephropathy may be an indicator of the severity of renal disease in patients with chronic glomerulonephritis.