文章简介遗传性癫痫是危害巨大的神经系统疾病,特别在婴幼儿癫痫病患中更加多发。近年来,全基因组测序发现,多种Slack钾离子通道的突变体可以引起遗传性癫痫,但其生物物理机制及对疾病的预防和治疗的影响尚未阐明。课题组利用爪蟾卵母细胞表达系统,将12个Slack通道的突变体异位表达到爪蟾的卵母细胞中,并采用膜片钳技术测量了这些通道突变体的钠离子敏感性和单通道开放 Introduction epilepsy genetic disease is a tremendous nervous system disease, especially in infants and young children with epilepsy more frequently. In recent years, whole genome sequencing has found that many kinds of Slack potassium channel mutants can cause hereditary epilepsy, but its biophysical mechanism and its impact on the prevention and treatment of the disease have not been elucidated. Using the Xenopus oocyte expression system, the team ectopically expressed 12 Slack channel mutants into Xenopus oocytes and measured the sodium ion sensitivity of these channel mutants using a patch-clamp technique Channel open