eIF3 p170与肺癌化疗相关性研究及对肺癌细胞药物敏感性的影响

来源 :中国临床药理学与治疗学 | 被引量 : 0次 | 上传用户:trung
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM: To evaluate the expression of eukaryotic initiation factors 3(eIF3) subunit 170 (eIF3 P170) in lung cancer tissues and its association with chemotherapy response of lung cancer. METHODS: 31 paraffin imbedded slices of lung cancer tissue from fiberscope diagnosis, 20 samples of benign lung tissues from inflammatory pseudotumor and bronchiectasis, and 10 samples of normal lung tissues from surgical operation were collected. The protein expression of eIF3 p170 in lung-cancer tissues, benign lesion tissues, and normal lung tissues were determined by immunohistochemical staining. RESULTS: The positive ratio of eIF3 p170 expression in lung cancer tissues is higher than those in normal and benign tissues, the lung cancer patients with a higher expression level of eIF3 p170 seems to be more sensitive to chemotherapy. Here, we also found that down-regulation of expression of eIF3 p170 could inhibit the growth of human lung adeno-carcinoma cell A549 cells and decrease the sensitivity of A549 to cisplatin. CONCLUSION: Our data suggest that eIF3 p170 may be involved in the pathogenesis of lung cancer and it appears to be associated with chemotherapy response of lung cancer. AIM: To evaluate the expression of eukaryotic initiation factors 3 (eIF3) subunit 170 (eIF3 P170) in lung cancer tissues and its association with chemotherapy response of lung cancer. METHODS: 31 paraffin imbedded slices of lung cancer tissue from fiberscope diagnosis, 20 samples of benign lung tissues from inflammatory pseudotumor and bronchiectasis, and 10 samples of normal lung tissues from surgical operation were collected. The protein expression of eIF3 pl70 in lung-cancer tissues, benign lesion tissues, and normal lung tissues were determined by immunohistochemical staining. : The positive ratio of eIF3 p170 expression in lung cancer tissues is higher than those in normal and benign tissues, the lung cancer patients with a higher expression level of eIF3 p170 seems to be more sensitive to chemotherapy. Here, we also found that down- regulation of expression of eIF3 p170 could inhibit the growth of human lung adeno-carcinoma cell A549 cells and decrease the sensitivity of A54 9 to cisplatin. CONCLUSION: Our data suggest that eIF3 p170 may be involved in the pathogenesis of lung cancer and it appears to be associated with chemotherapy response of lung cancer.
其他文献
天车工“十不吊”的规定是从长期实践中总结出来的,千万违反不得,否则要出事故。 比如,“钢丝绳不合格不吊”。有人却不看钢丝绳好坏拿来就吊,甚至用铁丝代替钢丝绳吊活,十之
在推行国家公务员制度工作中,竞争上岗工作是实施公务员制度的重点与难点,搞得好不好,对一个单位整体推行工作起着至关重要的作用,不可等闲视之。从我们湖北省孝感市开展竞争上岗
寿阳县地处晋中东山地带,山峦起伏,沟壑纵横,耕地分布于川地、坡地梯田和丘陵地带,平均海拔1,200米,年平均气温7.3℃,一月份平均-9℃,绝对最低温度-29.4℃,七月份平均21.7℃
通过对电器隔离罩制件的分析,确定制件的成形工艺和成形工步,设计了多工位成形模具,使制件在一套模具上分别完成多个工序,实现产品的冲压成形和批量生产。该模具经实际生产验
民主建设中的漏洞与腐败的成因湖北石首市委党校姚家祥在来稿中认为,我国民主建设中的漏洞,为腐败现象的生存提供了条件。一是民主主体素质的发展不平衡和低下,为腐败现象的生成
20世纪后半叶“交叉学科”这个新名词进入人们视域,随后一部分人开始将舞蹈教育与运动医学、心理学、生理学等自然学科和人文学科相结合实现了学科交融,学科交融为舞蹈教育带
因为牵挂的人最近在伦敦,忍不住想说,要不帮我带一本原版《月亮与六便士》吧,最好是那种二手小书店里淘来的,带着点陈旧的气味。  于是想到很久前看过的一本小书《查令十字街84号》,里面有家“马克思与科恩书店”。书店已不复存在,但书却很有意思,抛开故事本身,倒觉得大家的读后感来得更温暖人心,这种反哺真是很罕见。本来,除了米其林餐厅,伦敦对我唯一的吸引力就是查令十字街和贝克街221号B座了。  译者在序中
期刊
英国激光及其应用会议于1964年9月15日—17日在伦敦 Savoy Place 电机工程师学会举行。会议是由英国电机工程师学会主办的。参加的国家有中国、英国、澳大利亚、加拿大、捷
国家公务员出国培训暂行规定人外发[1995]110号第一章总则第一条为保证国家公务员出国培训工作的科学化、规范化和制度化,根据《国家公务员暂行条例》,制定本暂行规定。第二条国家公务员
今年“安全月”期间,我随劳动人事部矿山安全检查团采访了山东省昌潍地区五井煤矿。这个煤矿是闻名遐迩的文明生产矿井。1980年由17个国家代表参加的联合国技术合作部小煤矿