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真性红细胞增多症(真红)末期可发生其他恶性血液病,最常见的是急性髓细胞白血病,而淋巴增殖性疾病少见,但有人推测真红的异常干细胞可引起淋巴系肿瘤。作者报告1例68岁女患者,1960年诊断为真红,先后经放疗及化疗,1977年后因症状消失、血红蛋白水平正常而停止治疗。1985年10月出现发热、虚弱、肢体疼痛及脾大等,血红蛋白7g/dl,白细胞计数21700/mm~3,原始细胞占12%,血小板13000/mm~3。骨穿为干抽。骨髓活检光镜检查、细胞化学染色及免疫学检查确诊为急性淋巴细胞白血病(急淋)。外周血原始细胞染色体分析发现有两种异常克隆:一种细胞系的染色体异常为del(20q),这是
Other polycythemia vera (true red) may occur at the end of other hematologic malignancies, the most common is acute myeloid leukemia, lymphoproliferative diseases rare, but it was speculated that true red abnormal stem cells can cause lymphoid tumors. The authors report a 68-year-old female patient who was diagnosed with true red in 1960 and treated with radiotherapy and chemotherapy successively and after 1977 with symptoms disappearing and normal hemoglobin levels stopped. October 1985 fever, weakness, limb pain and splenomegaly, hemoglobin 7g / dl, white blood cell count 21700 / mm ~ 3, 12% of primitive cells, platelets 13000 / mm ~ Bone wear dry pumping. Bone marrow biopsy light microscopy, cytochemical staining and immunological examination confirmed acute lymphoblastic leukemia (acute lymphoblastic). Chromosomal analysis of peripheral blood blasts revealed two abnormal clones: one of the cell lines had a chromosomal abnormality of del (20q), which is