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目的 了解乙肝病毒慢性感染者早期肾损伤情况及其可能存在的影响因素。方法 对 1 0 9例乙肝病毒慢性感染者进行尿α1微球蛋白 (尿α1 -MG)和尿微量白蛋白 (尿mALB)检测 (放免法 )以及HBVDNA检测。结果 1 0 9例乙肝病毒慢性感染者中 ,早期肾损伤有 54例 (49.54 % ) ,其中尿α1 -MG异常 43例 (39.45 % ) ,尿mALB异常 41例 (37.61 % ) ,同时异常 30例 (2 7.52 % )。 67例HB VDNA阳性乙肝病毒慢性感染者早期肾损伤为 39例 (58.2 1 % ) ,42例HBVDNA阴性乙肝病毒慢性感染者早期肾病损伤为 1 5例 (35 .71 % ) ,二组间早期肾损伤率差异有统计学意义 (P <0 .0 5)。结论 早期肾损伤在HBV慢性感染者中可能普遍存在 ,尤以HBVDNA阳性者明显 ,对HBV慢性感染者进行早期肾损伤检测及抗病毒治疗 ,对于疾病的防治有重要的临床意义
Objective To understand the status of early renal injury and its possible influencing factors in patients with chronic hepatitis B virus infection. Methods Urine α1 microglobulin (urinary α1-MG) and urinary microalbuminuria (MALB) and radioimmunoassay (HBVDNA) were detected in 109 chronic hepatitis B patients. Results There were 54 cases (49.54%) of early renal damage in chronic hepatitis B virus infection, of which 43 cases (39.45%) had urinary α1-MG abnormality and 41 cases (36.61%) had abnormal urine mALB with abnormalities in 30 cases (2 7.52%). Thirty-nine cases (58.2%) of chronic renal failure patients with chronic hepatitis B virus (HBV) positive chronic hepatitis B infection and 15 cases (35.71%) early renal damage patients with chronic hepatitis B virus infection were found in 42 HBVDNA-negative patients The difference of injury rate was statistically significant (P <0.05). Conclusion Early renal injury may be prevalent in patients with chronic HBV infection, especially HBV DNA positive patients with HBV infection. Chronic kidney injury in HBV patients with early renal injury detection and antiviral therapy have important clinical significance for the prevention and treatment of the disease