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目的探讨奥曲肽联合大黄治疗轻型胰腺炎的临床疗效。方法选取涿鹿县医院2015年11月—2016年11月收治的轻型胰腺炎患者82例,依照治疗方式的不同分成单治组和联合组,各41例。单治组患者给予奥曲肽注射液治疗,联合组患者在单治组基础上加用中药大黄治疗,两组患者均持续治疗7 d。比较两组患者临床疗效及住院时间、腹痛腹胀缓解时间、血淀粉酶恢复正常时间、排气通便时间、呕吐消失时间,检测比较两组患者治疗前后尿淀粉酶、血白细胞计数与血淀粉酶变化情况,并观察两组患者不良反应发生情况。结果联合组患者临床疗效优于单治组(P<0.05)。联合组患者住院时间、腹痛腹胀缓解时间、血淀粉酶恢复正常时间、排气通便时间、呕吐消失时间短于单治组(P<0.05)。治疗前,两组患者尿淀粉酶、白细胞计数、血淀粉酶比较,差异无统计学意义(P>0.05);治疗后,联合组患者尿淀粉酶、白细胞计数及血淀粉酶低于单治组(P<0.05)。联合组患者不良反应发生率低于单治组(P<0.05)。结论奥曲肽联合大黄治疗轻型胰腺炎的临床疗效确切,可有效改善患者的临床症状及各项临床指标,且安全性好。
Objective To investigate the clinical efficacy of octreotide combined with rhubarb for the treatment of mild pancreatitis. Methods 82 cases of patients with mild pancreatitis admitted to Zhuolu Hospital from November 2015 to November 2016 were selected and divided into single treatment group and combined treatment group according to different treatment methods, 41 cases in each group. Patients in the monotherapy group were treated with octreotide injection. The patients in the combined group were treated with rhubarb on the basis of the single treatment group, and the patients in both groups were treated for 7 days. The clinical efficacy, hospitalization time, abdominal pain and abdominal distension time, blood amylase recovery time, exhaust laxative time and vomiting disappearance time were compared between the two groups. The urine amylase, white blood cell count and blood amylase Changes, and observed two groups of patients with adverse reactions occurred. Results The clinical efficacy of the combined group was better than that of the single group (P <0.05). The hospitalization time, abdominal pain and abdominal distension time, blood amylase recovery time, exhaust laxativeness and vomiting disappeared in the combined group were shorter than those in the single treatment group (P <0.05). Before treatment, urinary amylase, white blood cell count and blood amylase in the two groups had no significant difference (P> 0.05). After treatment, the urinary amylase, white blood cell count and blood amylase in the combined group were lower than those in the single group (P <0.05). The incidence of adverse reactions in the combination group was lower than that in the monotherapy group (P <0.05). Conclusion The clinical efficacy of octreotide combined with rhubarb for the treatment of mild pancreatitis is accurate, which can effectively improve the clinical symptoms and clinical indicators of patients and has good safety.