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目的探讨肺炎支原体肺炎(MPP)患儿血清中神经生长因子(NGF)和白细胞介素-15(IL-15)的水平变化及临床价值。方法选取2012年8月~2014年6月该院收治的70例MPP患儿作为研究组(其中重症组28例,轻症组42例),另选60例健康儿童作为对照组。以酶联免疫吸附法检测两组患儿的血清NGF和IL-15水平。结果 MPP患儿急性期IL-15水平为(243.17±63.21)pg/ml,NGF水平为(158.43±34.12)pg/ml,恢复期分别为(144.16±51.77)pg/ml和(98.76±21.37)pg/ml,均明显高于对照组〔(110.55±20.86)pg/ml、(30.54±12.08)pg/ml,P均<0.05〕,且急性期IL-15、NGF水平均显著高于恢复期,差异均有统计学意义(P<0.05)。在急性期时,重症组血清IL-15、NGF水平显著高于轻症组〔(286.47±53.31)pg/ml vs(212.14±41.78)pg/ml,(205.13±28.64)pg/ml vs(129.33±22.35)pg/ml〕,差异均有统计学意义(P<0.05);在恢复期时,重症组血清IL-15、NGF水平虽高于轻症组,但差异无统计学意义(P>0.05)。结论 MPP患儿血清中IL-15、NGF水平明显升高,当病情缓解时又都有所降低,这表明IL-15与NGF参与肺炎支原体感染的发病过程。
Objective To investigate the changes of serum levels of nerve growth factor (NGF) and interleukin-15 (IL-15) in children with Mycoplasma pneumoniae pneumonia (MPP) and its clinical value. Methods Seventy patients with MPP admitted to our hospital from August 2012 to June 2014 were selected as the study group (28 in the severe group and 42 in the mild group), and 60 healthy children were selected as the control group. Enzyme-linked immunosorbent assay was used to detect serum NGF and IL-15 levels in both groups. Results The levels of IL-15 in MPP children during the acute phase were (243.17 ± 63.21) pg / ml and the levels of NGF were (158.43 ± 34.12) pg / ml and the recoveries were (144.16 ± 51.77) pg / ml and (98.76 ± 21.37) pg / ml were significantly higher than those in the control group 〔(110.55 ± 20.86) pg / ml, (30.54 ± 12.08) pg / ml, P <0.05〕 , The differences were statistically significant (P <0.05). Serum levels of IL-15 and NGF in the severe group were significantly higher than those in the mild group [(286.47 ± 53.31) pg / ml vs (212.14 ± 41.78) pg / ml and (205.13 ± 28.64) pg / ml vs 129.33 ± 22.35) pg / ml〕, the differences were statistically significant (P <0.05); during the recovery period, the levels of serum IL-15 and NGF in the severe group were higher than those in the mild group, but the difference was not statistically significant (P> 0.05). Conclusion Serum levels of IL-15 and NGF in MPP patients were significantly higher than those in MPP patients, indicating that IL-15 and NGF are involved in the pathogenesis of Mycoplasma pneumoniae infection.