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雌激素对心血管系统的保护作用，是育龄妇女少患此类疾病的重要原因。本文以体外培养的小牛主动脉内皮细胞为实验材料，考察了雌二醇对血管内皮细胞抗氧化系统的影响。结果表明，0．5μg／ml雌二醇作用内皮细胞后，细胞内SOD活性显著增加，与此相对应，细胞内过氧化产物MDA的含量显著降低。提示该浓度的雌二醇能够提高细胞内的抗氧化能力，因而可能防止活性氧对内皮细胞的损伤，而这种损伤往往是动脉粥样硬化的开端。0．05μg／ml雌二醇显示类似的作用趋势，但差异未达到显著水平。5μg／ml雌二醇则对内皮细胞内SOD活性有降低趋势，并显著升高了细胞MDA的含量，表明雌二醇对内皮细胞的作用效果与激素水平有关，同时考察了不同剂量雌激素对内皮细胞老化过程中代谢残留物脂褐素含量的影响，未发现与对照间的显著差异。
The protective effect of estrogen on the cardiovascular system is an important reason that women of childbearing age suffer less from such diseases. In this study, aortic endothelial cells cultured in vitro were used as experimental materials to investigate the effect of estradiol on the antioxidant system of vascular endothelial cells. The results showed that 0.5μg / ml estradiol significantly increased the activity of intracellular SOD, and correspondingly, the content of intracellular peroxidation MDA significantly decreased. It is suggested that estradiol at this concentration can improve the intracellular antioxidant capacity and thus may prevent the damage of endothelial cells by reactive oxygen species, which is often the beginning of atherosclerosis. 0.05μg / ml estradiol showed a similar trend, but the difference did not reach significant level. 5μg / ml estradiol decreased the activity of SOD in endothelial cells, and significantly increased the content of MDA in the cells, indicating that the effect of estradiol on endothelial cells was related to the level of hormones. At the same time, different doses of estrogen The effect of lipofuscin content of metabolic residues during endothelial cell aging was not found to be significantly different from the control.