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目的探讨热性惊厥患儿治疗前后血清神经元特异性烯醇化酶(NSE)水平变化的意义。方法选取2012年1月至2015年1月收治的42例热性惊厥患儿作为研究对象,记为研究组;另选取同期收治的非神经系统疾病患儿39例为对照组,均行NSE检测,比较两组患儿的检测结果。结果研究组患儿血清NSE水平均明显高于对照组,差异有统计学意义(P<0.05);相关性分析显示,NSE水平与惊厥发生次数无关(P>0.05),但与惊厥持续时间成正相关(P<0.05)。结论热性惊厥发作后脑损害严重程度与NSE水平密切相关,可将血清NSE作为早期惊厥性脑损伤的客观诊断指标。
Objective To investigate the changes of serum neuron specific enolase (NSE) in children with febrile seizures before and after treatment. Methods Forty-two children with febrile seizures admitted from January 2012 to January 2015 were enrolled as study group. Another 39 children with non-neurological diseases were enrolled in this study. All patients underwent NSE , Comparing the test results of two groups of children. Results The serum level of NSE in the study group was significantly higher than that in the control group (P <0.05). Correlation analysis showed that the NSE level had no correlation with the number of convulsions (P> 0.05), but was positively correlated with the duration of convulsion Related (P <0.05). Conclusions The severity of brain injury after the onset of febrile seizures is closely related to the level of NSE, which may be used as an objective diagnostic indicator of early-onset convulsive brain injury.