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0 引言 1986年美国 Sells等 (The Mount Sinal MedicaCenter)将 HBV基因转染到人肝癌细胞 (Hep G2 )中 ,获得了能表达 HBV标志的细胞株 2 .2 .15细胞 ,并以此作为模型筛选抗 HBV的药物 ,进行基因结构及功能的研究 .然而 HBV在 2 .2 .15细胞中复制方式与自然感染的肝细胞有何
0 Introduction In 1986 Sells et al. (The Mount Sinal MedicaCenter) transfection of HBV gene into human hepatoma cells (Hep G2), cell lines can be obtained to express HBV markers 2.215 cells, and as a model screening Anti-HBV drugs, gene structure and function of the study However, HBV replication in 2.2.15 cells with naturally infected hepatocytes