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疟原虫的生活史包括配子体、裂殖子、环状体等多个阶段,先后寄生在多种类型的宿主细胞才完成完整的生命周期。在这些生活史中的不同虫期,疟原虫表现出明显的表型差异;在应对生存环境的改变时,其基因表达能够很精确地做出应对。近年来诸多研究表明,无论是这些生命阶段的转换,还是对宿主的适应,疟原虫表观遗传学方面的调控都起了很大的作用。对疟原虫表观遗传学的研究,有利于深入了解疟原虫与宿主的相互作用机制,对防治疟疾工作具有重要意义。本文从组蛋白修饰、DNA甲基化、非编码RNA编辑等方面介绍目前疟原虫表观遗传学研究进展。
Plasmodium life cycle, including gametocytes, merozoites, and many other stages of the ring, has been parasitic in a variety of types of host cells to complete the entire life cycle. Plasmodium showed significant phenotypic differences at these stages of life, and responded genetically to changes in living conditions. In recent years, many researches have shown that the regulation of malaria epigenetics plays an important role both in the transformation of these stages of life and adaptation of the host. The study of epigenetics of malaria parasites helps to understand the mechanism of interaction between malaria parasites and host, and is of great significance for malaria control. In this paper, the progress of epigenetics of Plasmodium was introduced from the aspects of histone modification, DNA methylation and non-coding RNA editing.