穿透角膜移植术是有效的复明手术之一。随着供体材料保存方法的改进及手术技巧的提高，移植失败率显著下降，而植片的免疫排斥反应越来越突出地成为移植失败的原因。本文对角膜移植术后免疫排斥反应的发生率、危险因素、临床表现，以及发生机制和治疗作一综述 Penetrating keratoplasty is one of the effective surgeries. With the improvement of donor material preservation methods and surgical skills, the failure rate of transplantation decreased significantly, and the immune rejection of implants became more and more the cause of graft failure. This article reviews the incidence of post-keratoplasty immune rejection, risk factors, clinical manifestations, as well as the mechanism and treatment of the review